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KMID : 0043319920150040356
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Archives of Pharmacal Research
1992 Volume.15 No. 4 p.356 ~ p.359
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Antitumor Activity of Psoralea corylifolia
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Ryu SY
Choi SU/Lee CO/Zee OP
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Abstract
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The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+)-bakuchiol 1 as an active principle of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, I.e. the A549, SK-OV-3, SK-MEL-2, XF498 and HCTIS. The synthesized 2,3-epoxide of (+)-bakuchiol 3 showed the similar acticity as the (+)-bakuchiol 1, whereas the other oxidantion derivaritives 4 and 5 including the acetyl-(+)-bakuchiol 2 showed a decreased activity.
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KEYWORD
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